Agilix - Genomics Proteomics and Biochip Technology

Agilix has achieved remarkable goals in its scientific research endeavors through cooperative research agreements with private sector and university intellectual property foundations.

Agilix has succeeded in the breakthrough development of a system capable of sequencing the entire genome of any organism. Using the patented system, DNA sequences of all possible genes are candidates for detection because the gene sequence of the organism of interest need not be known prior to analysis. This novel research tool employs a proprietary and novel universal microarray that eliminates the need for microarrays that are specific to a particular organism.

Agilix scientists have developed the most innovative multiplex labeling technology available. The Agilix revolutionary technology has helped to overcome one of the most significant limitations in proteomics today. This technology utilizes versatile, small, discrete labels of a proprietary composition, achieving significantly higher multiplex labeling than currently available labeling techniques. The unique properties of these patent labels allow the simultaneous measurement of more analytes than any other commercially available system. The labels can be attached to proteins of interest using standard chemistry techniques by means of direct labeling. Alternatively the labels can be attached to highly specific recognition molecules such as antibodies in a process known as indirect labeling.

The labels may also be incorporated directly into an organism or pathway of interest through a fusion process using the cell's own protein production machinery. The unique properties of the labels allow detection of multiple labels in complex biological samples, in solution, or in tissues. Importantly, accuracy is increased because measurement is accomplished in parallel, rather than through serial analysis.

In addition to these developing technologies, important advances in recent years have led to the development of bio-chips capable of the universal sequencing of DNA based on sequencing-by-hybridization (SBH) technology. This process employs synthetic oligomers or oligos as molecular probes for the detection of complementary sequence segments in DNA. After employing the SBH process, the complete sequence is derived using standard bioinformatics techniques.

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